Caylus was founded in 1988 by Enrique Gutiérrez de Calderón, José Antonio de Urbina and Peter Glidewell.
Caylus deals mainly in Spanish and Italian Old Masters, focusing on Spanish paintings from the Gothic to the Romantic period.The gallery also deals with Latin American Art. A catalogue is published every two years with contributions from specialized art historians. Caylus is also active in Spanish cultural life as one of the sponsor companies of the Fundación de Amigos del Museo del Prado, Fundación de Amigos del Museo de Artes Decorativas de Madrid, Asociación del Museo Nacional de Escultura de Valladolid and the Fundación de Arte Hispánico.
Caylus exhibits at the mayor international art Fairs such as TEFAF, Maastricht and Frieze Masters, London.